THE EFFECT OF ALLOPURINOL ON NA+K+ATPASE RELATED LIPID-PEROXIDATION IN ISCHEMIC AND REPERFUSED RABBIT KIDNEY

被引：21
|
作者：
ARICIOGLU, A [1 ]
AYDIN, S [1 ]
TURKOZKAN, N [1 ]
DURMUS, O [1 ]
机构：
[1] GAZI UNIV, FAC MED, DEPT GEN SURG, ANKARA, TURKEY
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1994年 / 25卷 / 02期
关键词：
NA+K+ATPASE; LIPID PEROXIDATION; ALLOPURINOL; KIDNEY;
D O I：
10.1016/0306-3623(94)90064-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Na+K+ATPase is a membrane bound enzyme whose activity is essential for maintenance of cell viability. Lipid peroxidation changes membrane fluidity and enzyme activity. 2. The purpose of this study was to investigate the effect of allopurinol (free radical scavenger) on Na+K+ATPase activity in rabbit kidney cortex membrane. In this in vivo study we created ischemia and reperfusion in rabbit kidneys. 3. Enzyme activity were low in ischemic and reperfused kidneys, compared to the controls. In allopurinol treated ischemic and reperfused groups, the levels of Na+K+ATPase activity were high compared to the untreated group. 4. It has been concluded that allopurinol may protect this enzyme activity.
引用
收藏
页码：341 / 344
页数：4
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