EFFECT OF CARBACHOL ON LUMINAL RELEASE OF SOMATOSTATIN FROM ISOLATED PERFUSED RAT DUODENUM

被引：17
|
作者：
FUJIMIYA, M
MCINTOSH, CHS
KIMURA, H
KWOK, YN
机构：
[1] UNIV BRITISH COLUMBIA,DEPT PHYSIOL,MRC,REGULATORY PEPTIDE GRP,VANCOUVER V6T 1W5,BC,CANADA
[2] SHIGA UNIV MED SCI,INST MOLEC NEUROBIOL,OTSU,SHIGA 52021,JAPAN
来源：
NEUROSCIENCE LETTERS | 1992年 / 145卷 / 02期
关键词：
RAT DUODENUM; SOMATOSTATIN-LIKE IMMUNOREACTIVITY; LUMINAL RELEASE; SOMATOSTATIN-28; SOMATOSTATIN-14; CARBACHOL;
D O I：
10.1016/0304-3940(92)90029-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The dynamic release of somatostatin-like immunoreactivity (SLI) from duodenum into the lumen was studied in the isolated, vascularly perfused rat duodenum. The luminal release of duodenal SLI was stimulated by a cholinergic agonist, carbachol, and the carbachol-induced release of SLI was completely blocked by atropine, but not by hexamethonium. These data suggest that the luminal release of SLI from rat duodenum is under the control of a cholinergic muscarinic stimulation. The ratio of somatostatin- 14 to somatostatin-28 in picograms was about 1 during basal release but increased to approximately 2 during carbachol stimulation.
引用
收藏
页码：229 / 233
页数：5
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