HEMODYNAMIC-EFFECTS OF WATER-SOLUBLE CONTRAST-MEDIA ON THE ISOLATED PERFUSED RAT-KIDNEY

被引：25
作者：
ELSAYED, AA
HAYLOR, JL
ELNAHAS, AM
SALZANO, S
MORCOS, SK
机构：
[1] UNIV SHEFFIELD,DEPT MED & PHARMACOL,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND
[2] TRENT REG HLTH AUTHOR,OPERAT RES UNIT,SHEFFIELD S10 3TH,S YORKSHIRE,ENGLAND
[3] NO GEN HOSP,DEPT RENAL MED,SHEFFIELD S5 7AU,S YORKSHIRE,ENGLAND
[4] NO GEN HOSP,DEPT RADIODIAG,SHEFFIELD S5 7AU,S YORKSHIRE,ENGLAND
来源：
BRITISH JOURNAL OF RADIOLOGY | 1991年 / 64卷 / 761期
关键词：
CONTRAST MEDIA; ISOLATED PERFUSED RAT KIDNEY; RENAL VASCULAR RESISTANCE; OSMOLARITY;
D O I：
10.1259/0007-1285-64-761-435
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The precise mechanism underlying the nephrotoxicity of radiocontrast media remains ill defined. In this study we have examined the direct effect of a wide range of low- and high-osmolar water-soluble contrast media (WSCM) on the vascular resistance of the isolated perfused rat kidney (IPRK). Water-soluble contrast media led to a significant fall in the renal perfusate flow and an increase in the renal vascular resistance (RVR). The magnitude of these haemodynamic changes was independent of the osomolality of the tested agents. This study shows a direct effect of WSCM on the vascular resistance of the isolated perfused rat kidney.
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页码：435 / 439
页数：5
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