SN-PROTOPORPHYRIN LOWERS SERUM BILIRUBIN LEVELS, DECREASES BILIARY BILIRUBIN OUTPUT, ENHANCES BILIARY HEME EXCRETION AND POTENTLY INHIBITS HEPATIC HEME OXYGENASE ACTIVITY IN NORMAL HUMAN-SUBJECTS

被引:54
作者
BERGLUND, L
ANGELIN, B
BLOMSTRAND, R
DRUMMOND, G
KAPPAS, A
机构
[1] KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT MED,METAB UNIT,S-14186 HUDDINGE,SWEDEN
[2] ROCKEFELLER UNIV HOSP,NEW YORK,NY 10021
关键词
D O I
10.1002/hep.1840080331
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:625 / 631
页数:7
相关论文
共 28 条
[1]  
ABRAHAM NG, 1986, BIOCHEM ARCH, V2, P253
[2]  
ANDERSON KE, 1984, J PHARMACOL EXP THER, V228, P327
[3]   DISPOSITION OF TIN-PROTOPORPHYRIN AND SUPPRESSION OF HYPERBILIRUBINEMIA IN HUMANS [J].
ANDERSON, KE ;
SIMIONATTO, CS ;
DRUMMOND, GS ;
KAPPAS, A .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 39 (05) :510-519
[4]  
CORNELIUS CE, 1985, J MED PRIMATOL, V14, P59
[5]   PREVENTION OF NEONATAL HYPERBILIRUBINEMIA IN RHESUS-MONKEYS BY TIN-PROTOPORPHYRIN [J].
CORNELIUS, CE ;
RODGERS, PA .
PEDIATRIC RESEARCH, 1984, 18 (08) :728-730
[6]   PREVENTION OF NEONATAL HYPERBILIRUBINEMIA BY TIN PROTOPORPHYRIN-IX, A POTENT COMPETITIVE INHIBITOR OF HEME OXIDATION [J].
DRUMMOND, GS ;
KAPPAS, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6466-6470
[7]   CHEMOPREVENTION OF NEONATAL JAUNDICE - POTENCY OF TIN-PROTOPORPHYRIN IN AN ANIMAL-MODEL [J].
DRUMMOND, GS ;
KAPPAS, A .
SCIENCE, 1982, 217 (4566) :1250-1252
[8]   AN EXPERIMENTAL-MODEL OF POSTNATAL JAUNDICE IN THE SUCKLING RAT - SUPPRESSION OF INDUCED HYPERBILIRUBINEMIA BY SN-PROTOPORPHYRIN [J].
DRUMMOND, GS ;
KAPPAS, A .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (01) :142-149
[9]   SUPPRESSION OF HYPERBILIRUBINEMIA IN THE RAT NEONATE BY CHROMIUM-PROTOPORPHYRIN - INTERACTIONS OF METALLOPORPHYRINS WITH MICROSOMAL HEME OXYGENASE OF HUMAN SPLEEN [J].
DRUMMOND, GS ;
KAPPAS, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 156 (06) :1878-1883