LONG-TERM EFFECTS OF TACRINE ON REGIONAL CEREBRAL BLOOD-FLOW CHANGES IN ALZHEIMERS-DISEASE

被引：21

作者：

MINTHON, L

NILSSON, K

EDVINSSON, L

WENDT, PE

GUSTAFSON, L

机构：

[1] Department of Psychogeriatrics, University of Lund

来源：

DEMENTIA | 1995年 / 6卷 / 05期

关键词：

TACRINE; DEMENTIA; TREATMENT; ALZHEIMERS DISEASE; REGIONAL CEREBRAL BLOOD FLOW;

D O I：

10.1159/000106954

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Regional cerebral blood flow (rCBF) was studied in patients with Alzheimer's disease (AD) before and after 14 months of tacrine treatment. The treated group was compared with an identical reference group of untreated AD patients. At baseline the two groups showed an identical rCBF and mean hemispheric blood flow. After 14 months the tacrine-treated patients showed a stable rCBF level and a significant increase in rCBF in the central-parietal regions, compared to the untreated reference group, who showed typical AD reductions in rCBF in these regions. Clinical outcome: 7 of 9 patients in the tacrine group were clinically unchanged or slightly improved during the study time. In the untreated group 8 of 11 patients had deteriorated in clinical assessments and none had improved. Long-term tacrine treatment in Alzheimer's disease may delay the progression of symptoms.

引用

页码：245 / 251

页数：7

共 28 条

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