EPITOPE MAPPING USING BACTERIOPHAGE PEPTIDE LIBRARIES

被引：47
|
作者：
LANE, DP
STEPHEN, CW
机构：
[1] University of Dundee, Dundee
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 02期
关键词：
D O I：
10.1016/0952-7915(93)90016-L
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vast libraries of random peptides displayed on the surface of bacteriophage potentially allow identification of specific ligands for any peptide receptor of interest. The sequence specificity of antibody-peptide interactions allows these libraries to be used to define and localize continuous epitopes. Remarkably clear-cut results have been obtained with some antibodies; however, the technique has not proved to be generally applicable.
引用
收藏
页码：268 / 271
页数：4
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