Understanding the genetics of coronary artery disease through the lens of noninvasive imaging

被引：0

作者：

Yang, Eunice ^{[1
]}

Vargas, Jose D. ^{[2
]}

Bluemke, David A. ^{[2
]}

机构：

[1] Johns Hopkins Sch Med, Baltimore, MD USA

[2] NIH, Radiol & Imaging Sci, 10 Ctr Dr,Room 10-1C355, Bethesda, MD 20892 USA

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2012年 / 10卷 / 01期

关键词：

atherosclerosis; carotid intima-media thickness; CCTA; complex genetic ana-lysis; coronary artery calcium; coronary artery disease; MRI; noninvasive cardiovascular imaging; PET; phenotype;

D O I：

10.1586/ERC.11.175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary artery disease is a common condition with a known heritable component that has spurred interest in genetic research for decades, resulting in a handful of candidate genes and an appreciation for the complexity of its genetic contributions. Recent advances in sequencing technologies have resulted in large-scale association studies, possibly adding to our current understanding of the genetics of coronary artery disease. Sifting through the statistical noise, however, requires the selection of effective phenotypic markers. New imaging technologies have improved our ability to detect subclinical atherosclerosis in a safe and reproducible manner in large numbers of patients. In this article, we propose that advances in imaging technology have generated improved phenotypic markers for genetic association studies of coronary artery disease.

引用

页码：27 / 36

页数：10

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