REGULATORY PEPTIDES AS A SOURCE OF NEW DRUGS - THE CLINICAL PROSPECTS FOR ANALOGS OF TRH WHICH ARE RESISTANT TO METABOLIC-DEGRADATION

被引：168
作者：
METCALF, G [1 ]
机构：
[1] RECKITT & COLMAN LTD,DEPT PHARMACOL,HULL HU8 7DS,N HUMBERSHIRE,ENGLAND
来源：
BRAIN RESEARCH REVIEWS | 1982年 / 4卷 / 03期
关键词：
D O I：
10.1016/0165-0173(82)90012-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
引用
收藏
页码：389 / 408
页数：20
相关论文
共 91 条
[1]  
AGARWAL RA, 1976, RES COMMUN CHEM PATH, V15, P743
[2]  
ALMQVIST S, 1972, FRONTIERS HORMONE RE, V1, P38
[3]   METABOLISM AND EXCRETION OF EXOGENOUS THYROTROPIN-RELEASING HORMONE IN HUMANS [J].
BASSIRI, RM ;
UTIGER, RD .
JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (07) :1616-1619
[4]   EEG AND BLOOD-PRESSURE EFFECTS OF TRH IN RABBITS [J].
BEALE, JS ;
WHITE, RP ;
HUANG, SP .
NEUROPHARMACOLOGY, 1977, 16 (7-8) :499-506
[5]  
BENNETT GW, 1981, BRIT J PHARMACOL, V74, pP227
[6]  
BHARGAVA HN, 1980, ENDOGENOUS EXOGENOUS, P549
[7]   PROLACTIN AND THYROTROPIN RELEASE IN MAN BY SYNTHETIC PYROGLUTAMYL-HISTIDYL-PROLINAMIDE [J].
BOWERS, CY .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 45 (04) :1033-+
[8]  
BREESE GR, 1975, J PHARMACOL EXP THER, V193, P11
[9]   METABOLISM AND PHARMACOKINETICS OF TRH AND AN ANALOG WITH ENHANCED NEURO-PHARMACOLOGICAL POTENCY [J].
BREWSTER, D ;
HUMPHREY, MJ ;
WAREING, MV .
NEUROPEPTIDES, 1981, 1 (03) :153-165
[10]   MODIFICATION OF THE PROLINE RESIDUE OF TRH ENHANCES BIOLOGICAL-ACTIVITY AND INHIBITS DEGRADATION [J].
BREWSTER, D ;
DETTMAR, PW ;
LYNN, AG ;
METCALF, G ;
MORGAN, BA ;
RANCE, MJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 66 (01) :65-71
12345678910