GENETIC-ACTIVITY OF THE HUMAN CARCINOGEN SULFUR MUSTARD TOWARDS SALMONELLA AND THE MOUSE BONE-MARROW

被引:27
作者
ASHBY, J
TINWELL, H
CALLANDER, RD
CLARE, N
机构
[1] ICI Central Toxicology Laboratory, Macclesfield,, Ches. Ches. SK10 4TJ, Alderley Park
来源
MUTATION RESEARCH | 1991年 / 257卷 / 03期
关键词
SULFUR MUSTARD; GENOTOXICITY; SALMONELLA; MOUSE BONE MARROW;
D O I
10.1016/0165-1110(91)90004-F
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Sulphur mustard is clearly mutagenic to the repair-proficient (uvrB+) strain G46 of S. typhimurium. It is also a micronucleus-inducing agent to the mouse bone marrow. These data strengthen the database indicating that most human carcinogens are genotoxic.
引用
收藏
页码:307 / 311
页数:5
相关论文
共 30 条
[1]   THE PRESENT LACK OF EVIDENCE FOR UNIQUE RODENT GERM-CELL MUTAGENS [J].
ADLER, ID ;
ASHBY, J .
MUTATION RESEARCH, 1989, 212 (01) :55-66
[2]   WEAK MUTAGENICITY TO SALMONELLA OF THE FORMALDEHYDE-RELEASING ANTI-TUMOR AGENT HEXAMETHYLMELAMINE [J].
ASHBY, J ;
CALLANDER, RD ;
ROSE, FL .
MUTATION RESEARCH, 1985, 142 (03) :121-125
[3]   REEVALUATION OF THE NEED FOR MULTIPLE SAMPLING TIMES IN THE MOUSE BONE-MARROW MICRONUCLEUS ASSAY - RESULTS FOR DMBA [J].
ASHBY, J ;
MIRKOVA, E .
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1987, 10 (03) :297-305
[4]   MUTAGENICITY TO BACTERIA, CULTURED-CELLS, AND RODENTS OF THE HUMAN CARCINOGEN CHLORNAPHAZINE [J].
ASHBY, J ;
LOQUET, C ;
ISHIDATE, M ;
CALLANDER, RD ;
ALBANESE, R .
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1988, 12 (04) :365-374
[5]  
Auerbach C., 1947, PROC ROY SOC EDINBURGH, V62B, P271
[6]   Production of mutations by allyl isothiocyanate [J].
Auerbach, C ;
Robson, JM .
NATURE, 1944, 154 :81-81
[7]   The modifying influence of dichloroethyl sulphide on the induction of tumours in mice by tar. [J].
Berenblum, I .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1929, 32 (03) :425-434
[8]   REACTION OF MONO- AND DI-FUNCTIONAL ALKYLATING AGENTS WITH NUCLEIC ACIDS [J].
BROOKES, P ;
LAWLEY, PD .
BIOCHEMICAL JOURNAL, 1961, 80 (03) :496-&
[9]   GENETIC TOXICOLOGY OF NITROGEN AND SULFUR MUSTARD [J].
FOX, M ;
SCOTT, D .
MUTATION RESEARCH, 1980, 75 (02) :131-168
[10]   USE OF REC- BACTERIA FOR TESTING OF CARCINOGENIC SUBSTANCES [J].
ICHINOTSUBO, D ;
MOWER, HF ;
SETLIFF, J ;
MANDEL, M .
MUTATION RESEARCH, 1977, 46 (02) :53-61