Mucoadhesive drug delivery system: An overview

被引：315

作者：

Boddupalli, Bindu M. ^{[1
]}

Mohammed, Zulkar N. K. ^{[1
]}

Nath, Ravinder A. ^{[2
]}

Banji, David ^{[1
]}

机构：

[1] Nalanda Coll Pharm, Dept Pharmaceut, Nalgonda 508001, Andhra Pradesh, India

[2] Osmania Univ, Fac Technol, Hyderabad 500013, Andhra Pradesh, India

来源：

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH | 2010年 / 1卷 / 04期

关键词：

Mucoadhesion; theories; mucoadhesive dosage forms;

D O I：

10.4103/0110-5558.76436

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. In this regard, this review covers the areas of mechanisms and theories of mucoadhesion, factors influencing the mucoadhesive devices and also various mucoadhesive dosage forms.

引用

页码：381 / 387

页数：7

共 42 条

[1] Mucoadhesive drug delivery systems [J].

Shaikh, Rahamatullah ;

Singh, Thakur Raghu Raj ;

Garland, Martin James ;

Woolfson, A. David ;

Donnelly, Ryan F. .

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2011, 3 (01) :89-100

[2]

Bernkop-Schnurch Andreas, 2005, Drug Discov Today Technol, V2, P83, DOI 10.1016/j.ddtec.2005.05.001

[3]

Chickering-III DE, 1999, BIOADHESIVE DRUG DEL, P1

[4] In situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability [J].

Choi, HG ;

Oh, YK ;

Kim, CK .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 165 (01) :23-32

[5]

Dias R, 2010, INDIAN J PHARM EDUC, V44, P183

[6] Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications [J].

Dodou, D ;

Breedveld, P ;

Wieringa, PA .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2005, 60 (01) :1-16

[7]

ELHADI SS, 2003, SAUDI PHARM J, V11, P150

[8]

GU JM, 1988, CRC CR REV THER DRUG, V5, P21

[9] PRECORNEAL RESIDENCE TIME IN HUMANS OF SODIUM HYALURONATE AS MEASURED BY GAMMA-SCINTIGRAPHY [J].

GURNY, R ;

RYSER, JE ;

TABATABAY, C ;

MARTENET, M ;

EDMAN, P ;

CAMBER, O .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1990, 228 (06) :510-512

[10] Low-frequency dielectric spectroscopy as a tool for studying the compatibility between pharmaceutical gels and mucous tissue [J].

Hägerström, H ;

Edsman, K ;

Stromme, M .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (09) :1869-1881

← 1 2 3 4 5 →