Frequency and genotype of human papillomavirus among Sudanese patients with head and neck tumours

被引：4

作者：

Ahmed, Hussain Gadelkarim ^{[1
]}

Mustafa, Saadalnour Abusail ^{[2
]}

Eltom, Faris Margani ^{[3
]}

Babiker, Ali Yousef Yahia ^{[4
]}

机构：

[1] Univ Hail, Coll Med, Dept Pathol, Hail, Saudi Arabia

[2] Elneelain Univ, Fac Med Lab Sci, Dept Histopathol & Cytol, Khartoum, Sudan

[3] Tyba Univ, Coll Appl Med Sci, Hail, Saudi Arabia

[4] Aqasseem Univ, Coll Appl Med Sci, Al Qassim, Saudi Arabia

来源：

ECANCERMEDICALSCIENCE | 2012年 / 6卷

关键词：

head and neck cancer; human papillomavirus; Sudanese;

D O I：

10.3332/ecancer.2012.282

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: The aim of this study was to determine the frequency and genotype of human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) and benign head and neck tumours. Methodology: A retrospective study was performed on 150 samples of patients diagnosed with HNSCCs and 50 samples obtained from patients diagnosed with benign head and neck tumours. Tumour DNA was amplified using polymerase chain reaction (PCR) with HPV consensus and multiplex primers. Results: Six of the 150 (4%) HNSCCs were HPV positive. HPV16 was the most prevalent type, with single infections present in 3/6 (50%) cases, whereas HPV18 and HPV33 were detected in 2/6 (33%) and 1/6 (17%), respectively. HPV infections were detected in 3 (50%) cases of oral cavity and 3 (50%) cases of pharynx. Conclusions: There was a significant association between HPV infection and HNSCCs (P < 0.05). The present data support the importance of HPV infection in oral and larynx tumours.

引用

页数：8

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