Preconditioning Stem Cells for In Vivo Delivery

被引：145

作者：

Sart, Sebastien ^{[1
]}

Ma, Teng ^{[2
]}

Li, Yan ^{[2
]}

机构：

[1] Ecole Polytech, CNRS, Hydrodynam Lab, UMR7646, Palaiseau, France

[2] Florida State Univ, FAMU FSU Coll Engn, Dept Chem & Biomed Engn, 2525 Pottsdamer St, Tallahassee, FL 32310 USA

来源：

BIORESEARCH OPEN ACCESS | 2014年 / 3卷 / 04期

基金：

美国国家科学基金会;

关键词：

aggregate formation; encapsulation; hydrogel; preconditioning; stem cells;

D O I：

10.1089/biores.2014.0012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cells have emerged as promising tools for the treatment of incurable neural and heart diseases and tissue damage. However, the survival of transplanted stem cells is reported to be low, reducing their therapeutic effects. The major causes of poor survival of stem cells in vivo are linked to anoikis, potential immune rejection, and oxidative damage mediating apoptosis. This review investigates novel methods and potential molecular mechanisms for stem cell preconditioning in vitro to increase their retention after transplantation in damaged tissues. Microenvironmental preconditioning (e.g., hypoxia, heat shock, and exposure to oxidative stress), aggregate formation, and hydrogel encapsulation have been revealed as promising strategies to reduce cell apoptosis in vivo while maintaining biological functions of the cells. Moreover, this review seeks to identify methods of optimizing cell dose preparation to enhance stem cell survival and therapeutic function after transplantation.

引用

页码：137 / 149

页数：13

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