共 22 条
- [21] WILLER JC, 1989, PAIN, V38, P1, DOI 10.1016/0304-3959(89)90065-1
- [22] WILLER JC, 1987, PRESSE MED, V16, P63
EVIDENCE OF A CENTRAL ANTINOCICEPTIVE EFFECT OF PARACETAMOL INVOLVING SPINAL 5HT(3) RECEPTORS
被引：53
作者：
PELISSIER, T
ALLOUI, A
PAEILE, C
ESCHALIER, A
机构：
[1] FAC MED CLERMONT FERRAND,PHARMACOL MED LAB,EQUIPE NPPUA,F-63001 CLERMONT FERRAND,FRANCE
[2] FAC MED SANTIAGO,DEPT FARMACOL,SANTIAGO 7,CHILE
来源：
关键词：
ANALGESIA;
PARACETAMOL;
5HT(3) RECEPTOR;
PAIN TEST;
C-FIBER-EVOKED REFLEX;
RATS;
D O I：
10.1097/00001756-199507310-00020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THIS study was carried out to determine both the effect of systemic paracetamol on the C-fibre evoked reflex activity, a test sensitive to centrally acting analgesic drugs, and the influence of an intrathecally administered 5HT(3) receptor antagonist, tropisetron. Paracetamol (200, 300, 400 mg kg(-1), i.v.) dose-dependently decreased (maximal effects -60+/-8%) the C-evoked responses for a duration of 90 min (for the lowest dose). This effect was totally suppressed by tropisetron (1 mu g, i.t.). These data confirm previous studies suggesting a central effect of this drug and demonstrate the involvement of a spinal 5HT(3) mediated serotonergic mechanism.
引用
收藏
页码：1546 / 1548
页数：3
相关论文