EVIDENCE OF A CENTRAL ANTINOCICEPTIVE EFFECT OF PARACETAMOL INVOLVING SPINAL 5HT(3) RECEPTORS

被引：53

作者：

PELISSIER, T

ALLOUI, A

PAEILE, C

ESCHALIER, A

机构：

[1] FAC MED CLERMONT FERRAND,PHARMACOL MED LAB,EQUIPE NPPUA,F-63001 CLERMONT FERRAND,FRANCE

[2] FAC MED SANTIAGO,DEPT FARMACOL,SANTIAGO 7,CHILE

来源：

NEUROREPORT | 1995年 / 6卷 / 11期

关键词：

ANALGESIA; PARACETAMOL; 5HT(3) RECEPTOR; PAIN TEST; C-FIBER-EVOKED REFLEX; RATS;

D O I：

10.1097/00001756-199507310-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THIS study was carried out to determine both the effect of systemic paracetamol on the C-fibre evoked reflex activity, a test sensitive to centrally acting analgesic drugs, and the influence of an intrathecally administered 5HT(3) receptor antagonist, tropisetron. Paracetamol (200, 300, 400 mg kg(-1), i.v.) dose-dependently decreased (maximal effects -60+/-8%) the C-evoked responses for a duration of 90 min (for the lowest dose). This effect was totally suppressed by tropisetron (1 mu g, i.t.). These data confirm previous studies suggesting a central effect of this drug and demonstrate the involvement of a spinal 5HT(3) mediated serotonergic mechanism.

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页码：1546 / 1548

页数：3

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