RIBOSOMAL HETEROGENEITY FROM CHROMATIN DIMINUTION IN ASCARIS-LUMBRICOIDES

被引：49
作者：
ETTER, A [1 ]
BERNARD, V [1 ]
KENZELMANN, M [1 ]
TOBLER, H [1 ]
MULLER, F [1 ]
机构：
[1] UNIV FRIBOURG,INST ZOOL,CH-1700 FRIBOURG,SWITZERLAND
来源：
SCIENCE | 1994年 / 265卷 / 5174期
关键词：
D O I：
10.1126/science.8052853
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The genome of Ascaris lumbricoides encodes both germline- and soma-specific proteins homologous to the eukaryotic small ribosomal protein (Rp) S19. The two Ascaris homologs differ by 24 amino acid substitutions and are both components of the small ribosomal subunits. In oocytes, the germline RpS19 homolog (RpS19G) predominates. During chromatin diminution, however, the gene is eliminated from all presomatic cells, and RpS19G is replaced by the product of the somatic gene (RpS19S). Chromatin diminution in A. lumbricoides causes a change in the protein composition of ribosomes during development and represents an alternative means of gene regulation.
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页码：954 / 956
页数：3
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