INCREASED NUMBER OF NADPH-D-POSITIVE NEURONS WITHIN THE SUBSTANTIA INNOMINATA IN ALZHEIMERS-DISEASE

被引：44

作者：

BENZING, WC ^{[1
]}

MUFSON, EJ ^{[1
]}

机构：

[1] RUSH PRESBYTERIAN ST LUKES MED CTR,RUSH ALZHEIMERS DIS CTR,DEPT NEUROL SCI,CHICAGO,IL 60612

来源：

BRAIN RESEARCH | 1995年 / 670卷 / 02期

关键词：

HUMAN; AGING; BASAL FOREBRAIN; HISTOCHEMISTRY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PLASTICITY;

D O I：

10.1016/0006-8993(94)01362-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NADPH-diaphorase histochemistry labels neurons containing nitric oxide synthase, the synthesizing for nitric oxide within the central nervous system. Quantitation revealed a statistically significant increase in the density of intensely (type 1) and moderately (type 2) but not lightly (type 3) NADPH-diaphorase stained neurons within the substantia innominata in AD as compared with age-matched controls. Increased numbers of NADPH-diaphorase neurons suggest excess nitric oxide production which may be neurotoxic to surrounding cholinergic neurons within the substantia innominata in Alzheimer's disease.

引用

页码：351 / 355

页数：5

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