HEMODYNAMIC EVALUATION OF BISOPROLOL AFTER CORONARY-ARTERY SURGERY IN PATIENTS WITH ALTERED LEFT-VENTRICULAR FUNCTION

被引：3
作者：
GOLDSTEIN, M
VINCENT, JL
LECLERC, JL
DHOLLANDER, A
MELOT, C
KAHN, RJ
机构：
[1] Department of Intensive Care, Erasme University Hospital, Free University of Brussels
来源：
CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 03期
关键词：
BISOPROLOL; CORONARY ARTERY BYPASS GRAFT; PROPRANOLOL; LEFT VENTRICULAR FUNCTION;
D O I：
10.1007/BF03029731
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bisoprolol is a new cardioselective beta-1 adrenergic blocking agent without intrinsic sympathomimetic activity hut with minimal effects on myocardial contractility. Bisoprolol was compared to propranolol in 24 patients after cardiac surgery for coronary artery bypass graft (CABG). Each patient had been treated preoperatively with beta-blocking agents and had a cineangiographic left ventricular ejection fraction between 35% and 55%. Patients were randomized to receive orally either 10 mg of propranolol three times a day or 5 mg of bisoprolol once a day. Both drugs resulted in a significant and similar decrease in heart rate. This was associated with significant decreases in cardiac index, stroke index, and thermodilution right ventricular ejection fraction 6 hours after administration of propranolol, but not after bisoprolol. Systolic function measured by Doppler techniques significantly increased in the 10 postoperative days in patients under bisoprolol but not significantly after propranolol. Each drug was well tolerated during the 10 postoperative days, and the recovery was uneventful in each patient. These results indicate that in patients with altered systolic function after CABG, bisoprolol is susceptible to reduce heart rate with less cardiovascular alteration than propranolol.
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收藏
页码：629 / 634
页数：6
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