PLATELET FACTOR-IV MESSENGER-RNA EXPRESSION IN HUMAN ERYTHROLEUKEMIC CELLS - REGULATION BY PHORBOL ESTERS AND CERTAIN CYTOKINES

被引：0

作者：

HUNT, P

HOKOM, MM

FISHER, CA

JACOBSEN, FW

WIEMANN, B

MARTIN, FH

机构：

[1] AMGEN INC, BIOCHEM LAB, Thousand Oaks, CA 91320 USA

[2] AMGEN INC, BIOMED SCI LAB, THOUSAND OAKS, CA 91320 USA

来源：

EXPERIMENTAL HEMATOLOGY | 1991年 / 19卷 / 08期

关键词：

HEL CELLS; PHORBOL MYRISTATE ACETATE (PMA); PLATELET FACTOR-IV (PF 4); MESSENGER RNA; CYTOKINES;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Developing megakaryocytes are distinguished from progenitor cells by the appearance of platelet proteins such as platelet factor 4 (PF 4). The human erythroleukemic cell line HEL can also be induced to produce PF 4 by incubation in phorbol esters. HEL cells were used here as a model system in which to study the phenomenon of inducible PF 4 production at both the mRNA and protein levels. The cytokines interleukin I-beta (IL-1-beta), interleukin 3 (IL-3), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), erythropoietin (EPO), and transforming growth factor-beta (TGF-beta) were also evaluated for their effects on PF 4 mRNA induction in HEL cells.

引用

页码：779 / 784

页数：6