GENETIC-VARIATION WITHIN AND BETWEEN LINES OF DIABETES PRONE AND NON-DIABETES-PRONE BB-RATS - ALLELE DISTRIBUTION OF 8 PROTEIN MARKERS

被引：8

作者：

PRINS, JB ^{[1
]}

HERBERG, L ^{[1
]}

DENBIEMAN, M ^{[1
]}

VANZUTPHEN, LFM ^{[1
]}

机构：

[1] UNIV DUSSELDORF,DIABET RES INST,W-4000 DUSSELDORF 1,GERMANY

来源：

LABORATORY ANIMALS | 1991年 / 25卷 / 03期

关键词：

BB-RAT; GENETIC CHARACTERIZATION; BIOCHEMICAL MARKERS;

D O I：

10.1258/002367791780808446

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Twenty-four inbred and 2 outbred lines of the BB rat have been genetically characterized by establishing the allele distribution of 8 monogenic protein markers. The marker genes are: plasma alkaline phosphatase-1 (Alp-1), catalase-1 (Cs-1), carboxylesterases (Es-1, Es-2, Es-14), glyoxalase I (Glo-1), group specific component (Gc), and haemoglobin-beta-chain (Hbb). At least 3 linkage groups are represented by this set of markers. Genetic variation was found both within and between lines. Within-line variation was observed in 4 lines, including the 2 outbred lines. The other 22 lines could be subdivided into 4 groups, each representing a unique allele distribution pattern.

引用

页码：207 / 211

页数：5

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