PROTEIN OXIDATIVE DAMAGE IS ASSOCIATED WITH LIFE EXPECTANCY OF HOUSEFLIES

被引：294
作者：
SOHAL, RS
AGARWAL, S
DUBEY, A
ORR, WC
机构：
[1] Department of Biological Sciences, Southern Methodist University, Dallas
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 15期
关键词：
AGING; OXYGEN FREE RADICALS; PROTEIN OXIDATION; OXIDATIVE STRESS;
D O I：
10.1073/pnas.90.15.7255
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The objective of this study was to test some of the predictions of the oxidative-stress hypothesis of aging, which postulates that aging is causally associated with the molecular damage inflicted by reactive oxygen species. Protein carbonyl content was used as an index of molecular oxidative modifications. The carbonyl content was found to be associated with the physiological age or life expectancy of flies rather than with their chronological age. Exposure of flies to sublethal hyperoxia (100% oxygen) irreversibly enhanced the carbonyl content of the flies and decreased their rate of oxygen consumption. Results of this study indicate that protein carbonyl content may be a biomarker of aging and support the general concept that oxidative stress may be a causal factor in the aging process.
引用
收藏
页码：7255 / 7259
页数：5
相关论文
共 34 条
[1]   ENDOGENOUS OXIDATIVE DNA DAMAGE, AGING, AND CANCER [J].
AMES, BN .
FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 7 (3-6) :121-128
[2]  
[Anonymous], 1974, ESTIMATION CATALASE
[3]   REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE [J].
CARNEY, JM ;
STARKEREED, PE ;
OLIVER, CN ;
LANDUM, RW ;
CHENG, MS ;
WU, JF ;
FLOYD, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3633-3636
[4]   ANALYSIS OF THE EFFECTS OF INDIVIDUAL VARIATION AND SELECTIVE MORTALITY ON POPULATION AVERAGES IN AGING POPULATIONS [J].
DONATO, H ;
HOSELTON, MA ;
SOHAL, RS .
EXPERIMENTAL GERONTOLOGY, 1979, 14 (03) :133-140
[5]   RELATIONSHIP BETWEEN SUPEROXIDE ANION RADICAL GENERATION AND AGING IN THE HOUSEFLY, MUSCA-DOMESTICA [J].
FARMER, KJ ;
SOHAL, RS .
FREE RADICAL BIOLOGY AND MEDICINE, 1989, 7 (01) :23-29
[6]  
FENN WO, 1967, J PHYSL, V213, P663
[7]  
Finch C. E., 1990, SENESCENCE GENOME
[8]   INACTIVATION OF KEY METABOLIC ENZYMES BY MIXED-FUNCTION OXIDATION REACTIONS - POSSIBLE IMPLICATION IN PROTEIN-TURNOVER AND AGING [J].
FUCCI, L ;
OLIVER, CN ;
COON, MJ ;
STADTMAN, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1521-1525
[9]   THE AGING PROCESS [J].
HARMAN, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :7124-7128
[10]   LIFE-SPAN SHORTENING OF THE NEMATODE CAENORHABDITIS-ELEGANS UNDER HIGHER CONCENTRATIONS OF OXYGEN [J].
HONDA, S ;
MATSUO, M .
MECHANISMS OF AGEING AND DEVELOPMENT, 1992, 63 (03) :235-246
1234