PHARMACOLOGY OF INHALED CAPSAICIN IN HUMANS

被引：35
作者：
FULLER, RW
机构：
[1] Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, Ducane Road
来源：
RESPIRATORY MEDICINE | 1991年 / 85卷
关键词：
D O I：
10.1016/S0954-6111(06)80251-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inhaled capsaicin in humans causes cough and transient increase in airways resistance: both these effects appearto be through stimulation of sensory nerves in the airway. It has therefore been possible to study the effect of pharmacological agents on these two reflexes. The induced cough can be modulated by using opiates and local anaesthetics and the increase in airways resistance by anticholinergic agents. The use of inhaled capsaicin has therefore proved a useful human model for the study of novel treatments of cough. © 1991, Baillière Tindall. All rights reserved. All rights reserved.
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页码：31 / 34
页数：4
相关论文
共 29 条
[1]   NEUROPHARMACOLOGY OF EMESIS INDUCED BY ANTI-CANCER THERAPY [J].
ANDREWS, PLR ;
RAPEPORT, WG ;
SANGER, GJ .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (09) :334-341
[2]   HISTAMINE IS RELEASED FROM SKIN BY SUBSTANCE-P BUT DOES NOT ACT AS THE FINAL VASODILATOR IN THE AXON REFLEX [J].
BARNES, PJ ;
BROWN, MJ ;
DOLLERY, CT ;
FULLER, RW ;
HEAVEY, DJ ;
IND, PW .
BRITISH JOURNAL OF PHARMACOLOGY, 1986, 88 (04) :741-745
[3]  
CHOUDRY NB, 1990, J PHYSIOL-LONDON, V422, pP33
[4]   EFFECT OF 443C81 ON THE RESPIRATORY RESPONSES TO CAPSAICIN IN HUMANS [J].
CHOUDRY, NB ;
GRAY, SJ ;
CALLAGHAN, JM ;
POSNER, J ;
FULLER, RW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (03) :1095-1095
[5]   SENSITIVITY OF THE HUMAN COUGH REFLEX - EFFECT OF INFLAMMATORY MEDIATORS PROSTAGLANDIN-E2, BRADYKININ, AND HISTAMINE [J].
CHOUDRY, NB ;
FULLER, RW ;
PRIDE, NB .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (01) :137-141
[6]  
CHOUDRY NB, 1990, EUR RESPIR J, V3, P579
[7]  
CHOUDRY NB, 1990, BRIT J PHARMACOL, V99, pP41
[8]  
CHOUDRY NB, 1989, EUR RESPIR J, V2, pS390
[9]  
CHOUDRY NB, 1990, THORAX, V45, pP311
[10]   CAPSAICIN INHALATION IN MAN AND THE EFFECTS OF SODIUM CROMOGLYCATE [J].
COLLIER, JG ;
FULLER, RW .
BRITISH JOURNAL OF PHARMACOLOGY, 1984, 81 (01) :113-117
123