STRUCTURAL REQUIREMENTS FOR OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY THIOLS

被引：30

作者：

WOOD, JL ^{[1
]}

GRAHAM, A ^{[1
]}

机构：

[1] WELLCOME RES LABS,DIV BIOL,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

FEBS LETTERS | 1995年 / 366卷 / 01期

关键词：

ATHEROSCLEROSIS; OXIDIZED LDL; MACROPHAGE; SMOOTH MUSCLE CELL; THIOL; SUPEROXIDE;

D O I：

10.1016/0014-5793(95)00494-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidation of low-density lipoprotein (LDL) by macrophages, endothelial cells and smooth muscle cells, may be mediated by production of free thiols in the presence of transition metals. We examined the structural requirements, within a series of cysteinyl derivatives, for oxidation of thiols and of LDL in Hams F10 medium. The primary mechanism by which such thiols mediate oxidation of LDL is largely independent of superoxide production, but strongly correlated with the susceptibility of each thiol to iron-catalysed auto-oxidation. These effects are compared and contrasted with thiol-dependent oxidation of LDL by stimulated human monocytes and macrophages.

引用

页码：75 / 80

页数：6

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