THE ACTION OF A CALCITONIN GENE-RELATED PEPTIDE ANTAGONIST IN HUMAN SKIN

被引：4

作者：

HAYES, NA

BUNKER, CB

MARSHALL, I

DOWD, PM

FOREMAN, JC

机构：

[1] UNIV LONDON UNIV COLL,DEPT PHARMACOL,GOWER ST,LONDON WC1E 6BT,ENGLAND

[2] UNIV LONDON UNIV COLL,SCH MED,DEPT DERMATOL,LONDON WC1E 6BT,ENGLAND

来源：

AGENTS AND ACTIONS | 1993年 / 38卷

关键词：

D O I：

10.1007/BF01996463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The CGRP antagonist, CGRP8 - 37, antagonized the ability of CGRP to increase blood flow in human skin and cause erythema. The mechanism of the antagonist effect of CGRP8 - 37 on the CGRP-induced erythema was an increase by the antagonist of the rate of decay of the CGRP-induced erythema. Since CGRP8 - 37 activates rat peritoneal mast cells to release their granular contents, we conclude that the antagonism by CGRP8 - 37 of the effect of CGRP in human skin is caused by an increase in the rate of degradation of CGRP by protease released from skin mast cells by CGRP8 - 37. It was not possible to demonstrate any antagonistic effect of CGRP8 - 37 on the CGRP receptor mediating increased blood flow in human skin.

引用

页码：C212 / C214

页数：3

共 8 条

[1] INTERACTIONS BETWEEN THE TACHYKININS AND CALCITONIN GENE-RELATED PEPTIDE LEAD TO THE MODULATION OF EDEMA FORMATION AND BLOOD-FLOW IN RAT SKIN [J].