INDUCTION OF INTERLEUKIN-2 MESSENGER-RNA INHIBITED BY CYCLOSPORIN-A

被引：482

作者：

ELLIOTT, JF

LIN, YA

MIZEL, SB

BLEACKLEY, RC

HARNISH, DG

PAETKAU, V

机构：

[1] UNIV ALBERTA, DEPT BIOCHEM, EDMONTON T6G 2H7, ALBERTA, CANADA

[2] DUPONT CO, DEPT CENT RES & DEV, GLENOLDEN, PA 19036 USA

[3] PENN STATE UNIV, MICROBIOL PROGRAM, UNIVERSITY PK, PA 16802 USA

来源：

SCIENCE | 1984年 / 226卷 / 4681期

关键词：

D O I：

10.1126/science.6334364

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclosporin A blocked production of the lymphokine interleukin 2 by activated T lymphocytes. In a human and a murine [mouse] cell line this inhibition reflected an absence of interleukin 2 mRNA. Under conditions in which these cells are normally stimulated to secrete high levels of interleukin 2, they failed to do so in the presence of cyclosporin A. In both cell lines this failure was accompanied by an absence of interleukin 2 messenger accumulation. [The use of this drug as an immunosuppressant in humans was outlined.].

引用

页码：1439 / 1441

页数：3

共 14 条

[1]

BLEACKLEY RC, 1981, J IMMUNOL, V127, P2432

[2]

BLEACKLEY RC, 1982, J IMMUNOL, V128, P758

[3] TRANSLATION OF LYMPHOCYTE MESSENGER-RNA FOR MOUSE COLONY STIMULATING FACTOR [J].