3-D retina organoids: Building platforms for therapies of the future

被引：11
作者：
Mazerik, Jessica N. [1 ]
Becker, Steven [1 ]
Sieving, Paul A. [1 ]
机构：
[1] NEI, NIH, 31 Ctr Dr,6A03, Bethesda, MD 20892 USA
来源：
CELL MEDICINE | 2018年 / 10卷
关键词：
Retina; organoid; precision medicine; regenerative medicine; stem cells; drug screening;
D O I：
10.1177/2155179018773758
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Across scientific disciplines, 3-D organoid culture systems offer platforms to integrate basic research findings with clinical care. The National Eye Institute mounted a $1.1 million 3-D Retina Organoid Challenge. Organoids developed through the Challenge will be valuable resources for drug screening, disease modeling, and precision and regenerative medicine.
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页数：6
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共 26 条
  • [1] Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa
    Arno, Gavin
    Agrawal, Smriti A.
    Eblimit, Aiden
    Bellingham, James
    Xu, Mingchu
    Wang, Feng
    Chakarova, Christina
    Parfitt, David A.
    Lane, Amelia
    Burgoyne, Thomas
    Hull, Sarah
    Carss, Keren J.
    Fiorentino, Alessia
    Hayes, Matthew J.
    Munro, Peter M.
    Nicols, Ralph
    Pontikos, Nikolas
    Holder, Graham E.
    Asomugha, Chinwe
    Raymond, F. Lucy
    Moore, Anthony T.
    Plagnol, Vincent
    Michaelides, Michel
    Hardcastle, Alison J.
    Li, Yumei
    Cukras, Catherine
    Webster, Andrew R.
    Cheetham, Michael E.
    Chen, Rui
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2016, 99 (06) : 1305 - 1315
  • [2] Stem cell-derived organoids and their application for medical research and patient treatment
    Bartfeld, Sina
    Clevers, Hans
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (07): : 729 - 738
  • [3] Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation
    Capowski, Elizabeth E.
    Simonett, Joseph M.
    Clark, Eric M.
    Wright, Lynda S.
    Howden, Sara E.
    Wallace, Kyle A.
    Petelinsek, Anna M.
    Pinilla, Isabel
    Phillips, M. Joseph
    Meyer, Jason S.
    Schneider, Bernard L.
    Thomson, James A.
    Gamm, David M.
    [J]. HUMAN MOLECULAR GENETICS, 2014, 23 (23) : 6332 - 6344
  • [4] Transplantation of Human Embryonic Stem Cell- Derived Retinal Cells into the Subretinal Space of a Non- Human Primate
    Chao, Jennifer R.
    Lamba, Deepak A.
    Klesert, Todd R.
    La Torre, Anna
    Hoshino, Akina
    Taylor, Russell J.
    Jayabalu, Anu
    Engel, Abbi L.
    Khuu, Thomas H.
    Wang, Ruikang K.
    Neitz, Maureen
    Neitz, Jay
    Reh, Thomas A.
    [J]. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2017, 6 (03):
  • [5] Chen HY, 2016, MOL VIS, V22, P1077
  • [6] Self-organizing optic-cup morphogenesis in three-dimensional culture
    Eiraku, Mototsugu
    Takata, Nozomu
    Ishibashi, Hiroki
    Kawada, Masako
    Sakakura, Eriko
    Okuda, Satoru
    Sekiguchi, Kiyotoshi
    Adachi, Taiji
    Sasai, Yoshiki
    [J]. NATURE, 2011, 472 (7341) : 51 - U73
  • [7] Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
    Gonzalez-Cordero, Anai
    West, Emma L.
    Pearson, Rachael A.
    Duran, Yanai
    Carvalho, Livia S.
    Chu, Colin J.
    Naeem, Arifa
    Blackford, Samuel J. I.
    Georgiadis, Anastasios
    Lakowski, Jorn
    Hubank, Mike
    Smith, Alexander J.
    Bainbridge, James W. B.
    Sowden, Jane C.
    Ali, Robin R.
    [J]. NATURE BIOTECHNOLOGY, 2013, 31 (08) : 741 - +
  • [8] iPSC-Derived Retina Transplants Improve Vision in rdl End-Stage Retinal-Degeneration Mice
    Mandai, Michiko
    Fujii, Momo
    Hashiguchi, Tomoyo
    Sunagawa, Genshiro A.
    Ito, Shin-ichiro
    Sun, Jianan
    Kaneko, Jun
    Sho, Junki
    Yamada, Chikako
    Takahashi, Masayo
    [J]. STEM CELL REPORTS, 2017, 8 (01): : 69 - 83
  • [9] Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment
    Meyer, Jason S.
    Howden, Sara E.
    Wallace, Kyle A.
    Verhoeven, Amelia D.
    Wright, Lynda S.
    Capowski, Elizabeth E.
    Pinilla, Isabel
    Martin, Jessica M.
    Tian, Shulan
    Stewart, Ron
    Pattnaik, Bikash
    Thomson, James A.
    Gamm, David M.
    [J]. STEM CELLS, 2011, 29 (08) : 1206 - 1218
  • [10] Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs
    Nakano, Tokushige
    Ando, Satoshi
    Takata, Nozomu
    Kawada, Masako
    Muguruma, Keiko
    Sekiguchi, Kiyotoshi
    Saito, Koichi
    Yonemura, Shigenobu
    Eiraku, Mototsugu
    Sasai, Yoshiki
    [J]. CELL STEM CELL, 2012, 10 (06) : 771 - 785
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