PROGNOSTIC-SIGNIFICANCE OF INTERLEUKIN-6 SERUM LEVELS IN PATIENTS WITH OVARIAN-CANCER

被引：166
作者：
SCAMBIA, G
TESTA, U
PANICI, PB
FOTI, E
MARTUCCI, R
GADDUCCI, A
PERILLO, A
FACCHINI, V
PESCHLE, C
MANCUSO, S
机构：
[1] UNIV CATTOLICA SACRO CUORE, DEPT OBSTET & GYNECOL, I-00168 ROME, ITALY
[2] IST SUPER SANITA, DEPT HEMATOL & ONCOL, I-00161 ROME, ITALY
[3] UNIV PISA, DEPT OBSTET & GYNECOL, PISA, ITALY
来源：
BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 02期
关键词：
INTERLEUKIN; 6; CYTOKINES; OVARIAN CANCER; SERUM MARKERS;
D O I：
10.1038/bjc.1995.71
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since patients with low IL-6 levels had a better survival than patients with high IL-6 levels (P = 0.0009). Multivariate analysis revealed that IL-6 positivity has an independent value.
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收藏
页码：354 / 356
页数：3
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