MOLECULAR-CLONING AND SEQUENCE DETERMINATION OF THE PEPLOMER PROTEIN GENE OF FELINE INFECTIOUS PERITONITIS VIRUS TYPE-I

被引：50
作者：
MOTOKAWA, K
HOHDATSU, T
AIZAWA, C
KOYAMA, H
HASHIMOTO, H
机构：
[1] KITASATO UNIV,SCH VET MED & ANIM SCI,DEPT VET INFECT DIS,TOWADA,AOMORI 034,JAPAN
[2] KITASATO INST,CTR BASIC RES,DEPT VIROL,TOKYO 108,JAPAN
来源：
ARCHIVES OF VIROLOGY | 1995年 / 140卷 / 03期
关键词：
D O I：
10.1007/BF01718424
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
cDNA clones spanning the entire region of the peplomer (S) gene of feline infectious peritonitis virus (FIPV) type I strain KU-2, were obtained and their complete nucleotide sequences were determined. A long open reading frame (ORF) encoding 1464 amino acid residues was found in the gene, which was 12 residues longer than the ORF of the FIPV type II strain 79-1146. The sequences of FIPV type I and mainly FIPV type II were compared. The homologies at the N- (amino acid residues 1-693) and C- (residues 694-1464) terminal halves were 29.8 and 60.7%, respectively. This was much lower than that between FIPV type II and other antigenically related coronaviruses, such as transmissible gastroenteritis virus of swine and canine coronavirus. This supported the serological relatedness of the viruses and confirmed that the peplomer protein of FIPV type I has distinct structural features that differ from those of antigenically related viruses.
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页码：469 / 480
页数：12
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