PROGNOSTIC-SIGNIFICANCE OF ERBB-2 (HER-2/NEU) ONCOGENE ACTIVATION IN HUMAN TUMORS

被引：0
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作者：
IMYANITOV, EN
KNYAZEV, PG
机构：
来源：
EKSPERIMENTALNAYA ONKOLOGIYA | 1993年 / 15卷 / 03期
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R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ERBB-2 (Her-2/NEU) oncogene is often amplified and/or overexpressed in certain human neoplasms, especially in the breast cancer (BC). This oncogene has attracted particular attention because some investigators demonstrated strong correlation between ERBB-2 activation and unfavourable clinical outcome in BC. However, there are also many controversial results. Nevertheless, at present ERBB-2 testing in BC seems to be useful in clinical practice. As to other tumour types, prognostic significance of ERBB-2 alteration is shown in ovarian, lung, gastric, urinary bladder and endometrial cancers. However, there are only a few reports devoted ot ERBB-2 in non-breast carcinomas, therefore these data should be confirmed before clinical application.
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页码：3 / 9
页数：7
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