X-CHROMOSOME INACTIVATION AND CELL MEMORY

被引：311
作者：
RIGGS, AD
PFEIFER, GP
机构：
[1] Department of Biology, Beckman Research Institute of the City of Hope, Duarte
来源：
TRENDS IN GENETICS | 1992年 / 8卷 / 05期
关键词：
D O I：
10.1016/0168-9525(92)90219-T
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mammalian X-chromosome inactivation is an excellent example of the faithful maintenance of a determined chromosomal state. As such, it may provide insight into the mechanisms for cell memory, defined as the faithful maintenance of a determined state in clonally derived progeny cells. We review here the aspects of X-chromosome inactivation that are relevant to cell memory and discuss the various molecular mechanisms that have been proposed to explain its occurrence, with emphasis on DNA methylation and a recently proposed mechanism that depends on the timing of replication.
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页码：169 / 174
页数：6
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