INCREASED LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND INTERLEUKIN-1-BETA (IL-1-BETA) IN TRACHEAL ASPIRATES OF NEWBORNS WITH PNEUMONIA

被引：15

作者：

BUCK, C ^{[1
]}

GALLATI, H ^{[1
]}

POHLANDT, F ^{[1
]}

BARTMANN, P ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,PHARMACEUT RES NEW TECHNOL,CH-4002 BASEL,SWITZERLAND

来源：

INFECTION | 1994年 / 22卷 / 04期

关键词：

D O I：

10.1007/BF01739905

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pneumonia is one of the major sites of infection in ventilated newborns. We investigated whether the cytokines IL-1 beta and TNF-alpha are detectable in tracheal aspirates of newborns with pneumonia as a diagnostic marker. All 12 infants with pneumonia had elevated levels of IL-1 beta (range 30-300 pg/ml) and TNF-alpha (range 60-680 pg/ml), whereas control infants (n=21; respiratory distress syndrome, very low birth weight or infants intubated preoperatively) had no detectable levels of IL-1 beta or TNF-alpha. In vitro investigations with mononuclear cells of umbilical cord blood were performed to rule out that exogenously added surfactant influences IL-1 beta and TNF-alpha production. It is concluded that IL-1 beta and TNF-alpha are important and specific mediators of neonatal pneumonia which may be of diagnostic importance.

引用

页码：238 / 241

页数：4

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