A COMPARATIVE-STUDY ON LIPID-PEROXIDATION IN CEREBRAL-CORTEX OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS

被引：0

作者：

ITO, H ^{[1
]}

TORII, M ^{[1
]}

SUZUKI, T ^{[1
]}

机构：

[1] KINKI UNIV,SCH MED,DEPT PATHOL,OSAKA,OSAKA 589,JAPAN

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1993年 / 25卷 / 12期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Lipid peroxidation and membrane-related enzyme changes in the cerebral cortex of stroke-prone rats (SHRSP) and normotensive rats were examined at 5 and 20 weeks of age. 2. In vivo formation of thiobarbituric acid-reactant substances was higher in SHRSP at 20 weeks of age and in vitro generation of free malondialdehyde was greater in SHRSP brains, both at 5 and 20 weeks of age, as compared with those in WKY. 3. Membrane-associated enzymes such as Na/K-ATPase and 5'-nucleotidase activities were lower in 20-week-old SHRSP than in age-matched WKY. 4. These results indicate how very prone the SHRSP brain is toward lipid peroxidation and subsequent membrane-related enzyme changes.

引用

页码：1801 / 1805

页数：5

共 26 条

[1] STRONG ATTENUATION OF ISCHEMIC AND POSTISCHEMIC BRAIN EDEMA IN RATS BY A NOVEL FREE-RADICAL SCAVENGER [J].