INTRAMOLECULAR CYCLIZATION - SYNTHESIS OF 9-OXO-4H,9H-PYRROLO[1,2-A]THIENO[2,3-D]PYRIDINE AND 4-OXO-4H,9H-PYRROLO[1,2-A]THIENO[2,3-D]PYRIDINE - SYNTHESIS OF PYRROLO[1,2-A]THIENO[3,2-E][1,4]DIAZEPINE AND PYRROLO[1,2-A]THIENO[2,3-E][1,4]DIAZEPINE

Synthesis of 1-(2- or 3-thienylmethyl)pyrrole and some derivatives are described from halogenomethylthiophenes. The intramolecular cyclisation of carboxylic acid 19 and 20 leads to pyrrolothienopyridines 22 and 23. On the other hand azide-aldehydes 29 and 30 in aqueous acid mixture gave the pyrrolo[1,2-alpha]thieno[3,2-e][1,4]diazepine and the pyrrolo[1,2-alpha]thieno[2,3-eI1,4]diazepine.