SEX AND AGE-DEPENDENT RESPONSE OF PYRUVATE-KINASE OF BRAIN OF RAT TO ESTRADIOL AND TESTOSTERONE

被引：5

作者：

CHAINY, GBN ^{[1
]}

KANUNGO, MS ^{[1
]}

机构：

[1] BANARAS HINDU UNIV, DEPT ZOOL, BIOCHEM LAB, VARANASI 221005, INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 72卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(76)80200-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of estradiol and testosterone on pyruvate kinase of the cerebral hemisphere of 7, 38 and 78 wk old male and female rats were studied. The activity of the enzyme is highest in immature rats of both the sexes and decreases thereafter. Castration decreases its activity in all the ages of both the sexes except in adult males. Estradiol induces the enzyme in castrated rats of both the sexes of the 3 ages. The pattern of induction differs with dose and sex of the animal. Testosterone has no striking effect on the enzyme level of both sexes. These findings are discussed in relation to the differential responsiveness of genes at various phases of the life span of the rat.

引用

页码：777 / 781

页数：5

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