HIGHER ENVIRONMENTAL TEMPERATURE-INDUCED INCREASE OF BODY-TEMPERATURE - INVOLVEMENT OF CENTRAL OPIOIDERGIC-GABAERGIC INTERACTION

被引:7
作者
GHOSH, S [1 ]
PODDAR, MK [1 ]
机构
[1] UNIV COLL SCI CALCUTTA, DEPT BIOCHEM, CALCUTTA 700019, W BENGAL, INDIA
关键词
ENVIRONMENTAL TEMPERATURE; BODY TEMPERATURE; GABA; CHOLINE; OPIOID;
D O I
10.1016/0091-3057(95)00001-D
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Exposure (2 h) of male albino rats to higher environmental temperature (HET, 40 degrees C) significantly increased the body temperature (BT). Administration of bicuculline (1 mg/kg, IP), physostigmine (0.2 mg/kg, IP), or their combination significantly raised the BT of normal rats (kept at 28 degrees C) or of HET-exposed rats. Atropine (5 mg/kg, IP) abolished the hyperthermic effect of bicuculline in normal and HET-exposed rats. The BT of normal and HET-exposed rat was increased with morphine (1 mg/kg, IP) and was reduced with naloxone (1 mg/kg, IP). Bicuculline or physostigmine-induced rise in BT of HET-exposed rats was potentiated following cotreatment of physostigmine with morphine. Atropine-induced hypothermia was abolished due to the cotreatment of atropine with morphine in HET-exposed rats. Further, (morphine + bicuculline)induced hyperthermia in HET-exposed rats was potentiated with physostigmine but was attenuated with atropine. In normal rats (kept at 28 degrees C), only atropine attenuated(morphine + bicuculline)-induced hyperthermia. L-Dopa + carbidopa or haloperidol did not significantly affect the BT of rats under similar conditions. These results suggest that short-term (2 h) exposure to HET activates the opioidergic neuron, which activates cholinergic activity through the inhibition of GABAergic system and, thus, enhances the BT.
引用
收藏
页码:73 / 76
页数:4
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