EFFECT OF VARYING SURFACE PATTERNS ON ANTIBIOTIC ELUTION FROM ANTIBIOTIC-LOADED BONE-CEMENT

被引：51

作者：

MASRI, BA

DUNCAN, CP

BEAUCHAMP, CP

PARIS, NJ

ARNTORP, J

机构：

[1] Department of Orthopaedics, Vancouver Hospital, Health Sciences Centre, Vancouver, BC

[2] University of British Columbia, Vancouver, BC

来源：

JOURNAL OF ARTHROPLASTY | 1995年 / 10卷 / 04期

关键词：

ANTIBIOTIC; ELUTION; CEMENT; SURFACE; ARTHROPLASTY; INFECTION;

D O I：

10.1016/S0883-5403(05)80145-7

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.

引用

页码：453 / 459

页数：7

共 28 条

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