Gene therapy for heart disease: molecular targets, vectors and modes of delivery to myocardium

被引：7

作者：

Scimia, Maria Cecilia ^{[1
]}

Cannavo, Alessandro ^{[1
]}

Koch, Walter J. ^{[1
]}

机构：

[1] Temple Univ Sch Med, Ctr Translat Med, Dept Pharmacol, 3500 N Broad St,MERB 941, Philadelphia, PA 19140 USA

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2013年 / 11卷 / 08期

关键词：

clinical trials; delivery methods; gene therapy; gene transfer; heart failure; large animal models; therapeutical targets; translational studies; vectors;

D O I：

10.1586/14779072.2013.818813

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite the numerous hurdles that gene therapy has encountered along the way, clinical trials over the last few years are showing promising results in many fields of medicine, including cardiology, where many targets are moving toward clinical development. In this review, the authors discuss the current state of the art in terms of clinical and preclinical development. They also examine vector technology and available vector-delivery strategies.

引用

页码：999 / 1013

页数：15

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