CELLULAR AND HUMORAL IMMUNE-RESPONSES TO RECOMBINANT ANTIGENS IN SHEEP INFECTED WITH TOXOPLASMA-GONDII

被引：8
作者：
COUGHLAN, SN
SAMAN, E
JACOBS, D
MERCIER, C
CESBRONDELAUW, MF
TREES, AJ
机构：
[1] INNOGENET BV, B-9052 GHENT, BELGIUM
[2] INST PASTEUR, F-59019 LILLE, FRANCE
来源：
PARASITE IMMUNOLOGY | 1995年 / 17卷 / 09期
关键词：
TOXOPLASMA GONDII; RECOMBINANT ANTIGENS; VACCINATION;
D O I：
10.1111/j.1365-3024.1995.tb00916.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune responses to recombinant fragments of the Toxoplasma gondii antigens ROP2 and GRA2 were investigated in sheep naturally and experimentally infected with T. gondii oocysts. Specific serum antibodies to C-terminal fragments were detected by ELISA. Cell-mediated responses in peripheral blood mononuclear cells were demonstrated by proliferation and interferon-gamma production following in vitro stimulation with the ROP2 fragment. This data indicates the presence of epitopes for sheep B cells in the recombinant GRA2 fragment and for both B and T cells in the ROP2 fragment.
引用
收藏
页码：465 / 468
页数：4
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