A NOVEL TECHNIQUE FOR THE ADMINISTRATION OF BRONCHODILATOR DRUGS FORMULATED AS DRY POWDERS TO THE ANESTHETIZED GUINEA-PIG

被引：9

作者：

UNDERWOOD, SL ^{[1
]}

LINGHAM, D ^{[1
]}

PEARSON, J ^{[1
]}

RAEBURN, D ^{[1
]}

机构：

[1] RHONE POULENC RORER LTD,DAGENHAM RES CTR,DAGENHAM RM10 7XS,ESSEX,ENGLAND

来源：

JOURNAL OF PHARMACOLOGICAL METHODS | 1991年 / 26卷 / 03期

关键词：

DRY POWDER FORMULATION; ADMINISTRATION DEVICES; ANESTHETIZED GUINEA PIGS; BRONCHODILATORS;

D O I：

10.1016/0160-5402(91)90044-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A technique is described for the administration of dry powder formulations of bronchodilator drugs to the anaesthetized guinea pig. The technique has been evaluated by comparing the efficacy of several bronchodilator drugs administered either as dry powders coformulated with a lactose carrier or as nebulized solutions. In each case, the dry powder formulation had comparable bronchodilator activity and duration of action to an equivalent dose administered as a nebulized solution. This technique offers a simple and inexpensive method for the rapid screening of bronchodilator drugs without the problems associated with aerosol administration.

引用

页码：203 / 210

页数：8

共 10 条

[1] WHAT DETERMINES WHETHER AN ELDERLY PATIENT CAN USE A METERED DOSE INHALER CORRECTLY [J].

ALLEN, SC ;

PRIOR, A .

BRITISH JOURNAL OF DISEASES OF THE CHEST, 1986, 80 (01) :45-49

[2] POTASSIUM CHANNELS AND AIRWAY FUNCTION - NEW THERAPEUTIC PROSPECTS [J].

BLACK, JL ;

BARNES, PJ .

THORAX, 1990, 45 (03) :213-218

[3]

KARLSSON JA, 1990, 8TH ACT PHARM CLIN A

[4]

LINDGREN S, 1987, EUR J RESPIR DIS, V70, P93

[5]

PAYNE AN, 1989, ASTHMA REV, V2, P1

[6] ERRORS IN INHALATION TECHNIQUE AND EFFICIENCY IN INHALER USE IN ASTHMATIC-CHILDREN [J].

PEDERSEN, S ;

FROST, L ;

ARNFRED, T .

ALLERGY, 1986, 41 (02) :118-124

[7]

RAEBURN D, 1989, American Review of Respiratory Disease, V139, pA608

[8]

THIESSEN B, 1980, EUR J RESPIR DIS, V61, P156

[9]

UNDERWOOD SL, 1990, BRIT J PHARMACOL, V99, pP883

[10]

YARBROUGH J, 1985, ANN ALLERGY, V55, P25

← 1 →