Effect of branched-chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients

被引：7

作者：

Ocana-Mondragon, Alicia ^{[1
]}

Antonio Mata-Marin, Jose ^{[2
]}

Uriarte-Lopez, Mario ^{[3
]}

Bekker-Mendez, Carolina ^{[1
]}

Alcala-Martinez, Enrique ^{[2
]}

Maria Ribas-Aparicio, Rosa ^{[4
]}

Antonio Uribe-Noguez, Luis ^{[1
,4
]}

Maria Rodriguez-Galindo, Dulce ^{[5
]}

de La Luz Martinez-Rodriguez, Maria ^{[1
]}

机构：

[1] Inst Mexicano Seguro Social, Ctr Med Nacl La Raza, Hosp Infectol, Unidad Invest Biomed Infectol & Inmunol, Ave Jacarandas Esquina Vallejo S-N, Mexico City 02990, DF, Mexico

[2] Inst Mexicano Seguro Social, Ctr Med Nacl La Raza, Hosp Infectol, Unidad Med Alta Especialidad, Mexico City 02990, DF, Mexico

[3] AYDSA Aminas & Derivados SA CV, Dept Invest & Desarrollo, Mexico City 06400, DF, Mexico

[4] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Programa Biomed & Biotecnol Mol, Dept Microbiol, Mexico City 11340, DF, Mexico

[5] Inst Mexicano Seguro Social, Ctr Med Nacl La Raza, Hosp Especialidades, Dept Psicol Clin,Unidad Med Alta Especialidad, Mexico City 02990, DF, Mexico

来源：

BIOMEDICAL REPORTS | 2018年 / 8卷 / 01期

关键词：

insulin resistance; branched-chain amino acids; chronic hepatitis C; health-related quality of life; hepatitis C virus;

D O I：

10.3892/br.2017.1012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The incidence rate of insulin resistance (IR) in patients with chronic hepatitis C (CHC) is high. Recently, branched-chain amino acids (BCAA) have been shown to attenuate IR in CHC patients; however, their effect on patient quality of life remains unclear. Therefore, the aim of the current prospective study was to determine the effects of BCAA supplement on IR and health-related quality of life (HR-QoL) in patients with CHC. In the study, 20 non-diabetic patients with CHC, who were non-responders to peginterferon-alpha and ribavirin, were recruited. Patients took a BCAA supplement once a day (30 g, after a minimum 10-h overnight fast) for 3 months. Serum levels of glucose, insulin, albumin, triglyc-erides and cholesterol were measured at 0 and 3 months. Additionally, IR was measured using the Homeostasis Model Assessment-IR, HR-QoL was assessed using the 36-item Short Form Health Survey and viral load was measured by reverse transcription polymerase chain reaction using Taqman probes. The Wilcoxon signed-rank test was used to determine statistical significance. The results indicated that 70% of the subjects were positive for IR, which decreased to 50% by the end of the study; furthermore, 85% of the subjects demonstrated some level of improvement. Overall, the BCAA treatment significantly decreased IR (P=0.006) and augmented serum albumin concentration (P=0.008) compared with basal values. Additionally, by the end of the treatment, viral load and triglycerides levels had decreased, though these results were not significant (P=0.084 and P=0.080, respectively). BCAA treatment also improved HR-QoL regarding role limitations due to physical health problems (P=0.017), role limitations due to emotional problems (P=0.026) and social function (P=0.008). In conclusion, BCAA supplementation reduced IR and improved HR-QoL in patients with CHC. These findings support the application of IR therapy as a possible therapeutic strategy for hepatitis C infection.

引用

页码：85 / 90

页数：6

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