LOSS OF BASIC FIBROBLAST GROWTH-FACTOR IN SUBSTANTIA-NIGRA NEURONS IN PARKINSONS-DISEASE

被引:91
作者
TOOYAMA, I
KAWAMATA, T
WALKER, D
YAMADA, T
HANAI, K
KIMURA, H
IWANE, M
IGARASHI, K
MCGEER, EG
MCGEER, PL
机构
[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,2255 WESBROOK MALL,VANCOUVER V6T 1Z3,BC,CANADA
[2] UNIV BRITISH COLUMBIA,CTR NEURODEGENERAT DISORDERS,VANCOUVER V6T 1W5,BC,CANADA
[3] SHIGA UNIV MED SCI,INST MOLEC NEUROBIOL,OTSU,SHIGA 52021,JAPAN
[4] TAKEDA CHEM IND LTD,TAKEDA BIOL RES LAB,OSAKA 532,JAPAN
关键词
D O I
10.1212/WNL.43.2.372
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Basic fibroblast growth factor (bFGF) has a neurotrophic effect on mesencephalic dopaminergic neurons in vitro and in vivo. To explore whether an abnormality in bFGF expression occurs in Parkinson's disease (PD), we examined the substantia nigra (SN) of six PD and eight control cases immunohistochemically using a monoclonal antibody to bFGF. The mean number of melanin-positive neurons in sections of PD SN was 30.3% of the control mean, but the number of bFGF-immunopositive neurons was only 4.7% of the control mean. bFGF-immunoreactivity was present in only 8.2% of PD, but in 93.7% of control melanin-positive neurons. These results suggest a profound depletion of bFGF in surviving dopaminergic neurons of the SN in PD, and this depletion may be related to the disease process.
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页码:372 / 376
页数:5
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