SEASONAL-VARIATION AND STABILITY OF CHLORINATED ORGANIC MUTAGENS IN DRINKING-WATER

被引：24
作者：
KINAE, N
SUGIYAMA, C
NASUDA, MY
GOTO, K
TOKUMOTO, K
FURUGORI, M
SHIMOI, K
机构：
来源：
WATER SCIENCE AND TECHNOLOGY | 1992年 / 25卷 / 11期
关键词：
DRINKING WATER; TRIHALOMETHANES; 3-CHLORO-4-DICHLOROMETHYL-5-HYDROXY-2(5H)-FURANONE(MX); SEASONAL VARIATION; STABILITY; MUTAGENIC ACTIVITY;
D O I：
10.2166/wst.1992.0310
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Seasonal variation of several chlorinated compounds, which are mutagenic and/or carcinogenic, in drinking water of Japan was examined by using a gas chromatograph equipped with an electron-capture detector and a gas chromatograph connected with a mass spectrometer. Water samples collected from 10 different points were submitted to physico-chemical analysis, and then subjected to the determination of chlorinated compounds. Potassium permanganate consumption values showed high scores in summer and autumn at all sampling points. Trihalomethanes(CHCl3, CHBrCl2, CHBr2Cl, CHBr3) had a tendency to show high values in summer at the urban areas. On the other hand, a new potent mutagen, 3-chloro-4-dichloromethyl-5-hydroxy-2-(5H)-furanone(MX) did not show any characteristic pattern in all seasons. The stability of MX under certain physical and biological conditions was also investigated. The mutagenic activity of MX on Salmonella typhimurium TA100 (-S9mix) decreased with increase of pH and temperature of the incubation solution. When MX was treated with human serum, the mutagenic activity disappeared in a short time. But, there was no change of the activity by treatment with human saliva.
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页码：333 / 340
页数：8
相关论文
共 16 条
[1]   METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].
AMES, BN ;
MCCANN, J ;
YAMASAKI, E .
MUTATION RESEARCH, 1975, 31 (06) :347-363
[2]  
FURIHATA C, IN PRESS MUTAT RES
[3]   DETERMINATION OF THE STRONG MUTAGEN 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE IN CHLORINATED DRINKING AND HUMIC WATERS [J].
HEMMING, J ;
HOLMBOM, B ;
REUNANEN, M ;
KRONBERG, L .
CHEMOSPHERE, 1986, 15 (05) :549-556
[4]  
HORTH H, 1989, PRD2038M WAT RES CTR
[5]   MUTAGENIC POTENCY OF CHLOROFURANONES AND RELATED-COMPOUNDS IN SALMONELLA [J].
ISHIGURO, Y ;
SANTODONATO, J ;
NEAL, MW .
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1988, 11 (02) :225-234
[6]  
KINAE N, IN PRESS MUTAT RES
[7]   AMES MUTAGENICITY AND CONCENTRATION OF THE STRONG MUTAGEN 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE AND OF ITS GEOMETRIC ISOMER E-2-CHLORO-3-(DICHLOROMETHYL)-4-OXO-BUTENOIC ACID IN CHLORINE-TREATED TAP WATERS [J].
KRONBERG, L ;
VARTIAINEN, T .
MUTATION RESEARCH, 1988, 206 (02) :177-182
[8]   IDENTIFICATION AND QUANTIFICATION OF THE AMES MUTAGENIC COMPOUND 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE AND OF ITS GEOMETRIC ISOMER (E)-2-CHLORO-3-(DICHLOROMETHYL)-4-OXOBUTENOIC ACID IN CHLORINE-TREATED HUMIC WATER AND DRINKING-WATER EXTRACTS [J].
KRONBERG, L ;
HOLMBOM, B ;
REUNANEN, M ;
TIKKANEN, L .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1988, 22 (09) :1097-1103
[9]   SALMONELLA-TYPHIMURIUM (TA100) MUTAGENICITY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE AND ITS OPEN-RING AND CLOSED-RING ANALOGS [J].
LALONDE, RT ;
COOK, GP ;
PERAKYLA, H ;
DENCE, CW ;
BABISH, JG .
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1991, 17 (01) :40-48
[10]   GENOTOXIC ACTIVITY OF ORGANIC-CHEMICALS IN DRINKING-WATER [J].
MEIER, JR .
MUTATION RESEARCH, 1988, 196 (03) :211-245
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