A ONE POT PROCEDURE FOR THE SYNTHESIS OF ALPHA-HYDROXYAMIDES FROM THE CORRESPONDING ALPHA-HYDROXYACIDS

被引：24

作者：

KELLY, SE

LACOUR, TG

机构：

[1] Process Research and Develooment, Central Research Division, Pfizer Inc., Groton., Connecticut

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 06期

关键词：

D O I：

10.1080/00397919208020850

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alpha-hydroxyamides are synthesized from the cooresponding alpha-hydroxyacids by generation of the bis-trimethylsilyl derivative and treating it with oxalyl chloride. Following addition of the appropriate amine, the TMS ether is hydrolyzed in the workup to provide the desired alpha-hydroxyamide. As summarized in Table 1, this reaction has proven to be general and compatible with chiral alpha-hydroxyacids affording the desired alpha-hydroxyamides in excellent yield (77-99%).

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页码：859 / 869

页数：11

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