A ONE POT PROCEDURE FOR THE SYNTHESIS OF ALPHA-HYDROXYAMIDES FROM THE CORRESPONDING ALPHA-HYDROXYACIDS

被引：22
作者：
KELLY, SE
LACOUR, TG
机构：
[1] Process Research and Develooment, Central Research Division, Pfizer Inc., Groton., Connecticut
来源：
SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 06期
关键词：
D O I：
10.1080/00397919208020850
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Alpha-hydroxyamides are synthesized from the cooresponding alpha-hydroxyacids by generation of the bis-trimethylsilyl derivative and treating it with oxalyl chloride. Following addition of the appropriate amine, the TMS ether is hydrolyzed in the workup to provide the desired alpha-hydroxyamide. As summarized in Table 1, this reaction has proven to be general and compatible with chiral alpha-hydroxyacids affording the desired alpha-hydroxyamides in excellent yield (77-99%).
引用
收藏
页码：859 / 869
页数：11
相关论文
共 22 条
123