TROPONIN ISOFORM SWITCHING IN THE DEVELOPING HEART AND ITS FUNCTIONAL CONSEQUENCES

被引：74
作者：
SCHIAFFINO, S
GORZA, L
AUSONI, S
机构：
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 01期
关键词：
D O I：
10.1016/1050-1738(93)90022-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The subunits of the troponin complex-troponin C, troponin T, and troponin I-are responsible for the Ca2+-dependent regulation of contractile activity in heart and skeletal muscle. Distinct troponin T and I isoforms, generated by different genes or by alternative splicing from the same gene, are expressed during cardiac development. Troponin switching affects the Ca2+ sensitivity of the contractile system and may account for the greater resistance to hypoxia and acidosis, and the impaired responsiveness to adrenergic stimulation of the fetal and neonatal heart.
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页码：12 / 17
页数：6
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