CANCER-ASSOCIATED RETINOPATHY WITH RETINAL PHLEBITIS

被引:31
作者
OHNISHI, Y [1 ]
OHARA, S [1 ]
SAKAMOTO, T [1 ]
KOHNO, T [1 ]
NAKAO, F [1 ]
机构
[1] HAYASHI EYE HOSP,FUKUOKA,JAPAN
关键词
D O I
10.1136/bjo.77.12.795
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
A 50-year-old man with cancer-associated retinopathy was investigated using light and electron microscopy, immunofluorescence studies, and western blotting. He had visual disturbance, ring-like scotoma, and night blindness bilaterally. There were narrowed retinal arterioles and dilated retinal venules. Oral corticosteroid therapy had positive effects. Immunostaining using the patient's serum revealed a positive reaction in the ganglion cell layer of normal retina. Western blotting showed that the patient's serum antibody reacted with normal retinal proteins of 24 and 48 kDa. Multiple metastases were evident at autopsy.
引用
收藏
页码:795 / 798
页数:4
相关论文
共 11 条
[1]   AN ULTRASTRUCTURAL-STUDY OF RETINAL PHOTORECEPTOR DEGENERATION ASSOCIATED WITH BRONCHIAL-CARCINOMA [J].
BUCHANAN, TAS ;
GARDINER, TA ;
ARCHER, DB .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1984, 97 (03) :277-287
[2]  
GRUNWALD GB, 1985, LANCET, V1, P658
[3]   A CLINICAL TRIAD TO DIAGNOSE PARANEOPLASTIC RETINOPATHY [J].
JACOBSON, DM ;
THIRKILL, CE ;
TIPPING, SJ .
ANNALS OF NEUROLOGY, 1990, 28 (02) :162-167
[4]   PHOTORECEPTOR DEGENERATION - POSSIBLE AUTOIMMUNE DISORDER [J].
KELTNER, JL ;
ROTH, AM ;
CHANG, RS .
ARCHIVES OF OPHTHALMOLOGY, 1983, 101 (04) :564-569
[5]   MANAGEMENT AND MONITORING OF CANCER-ASSOCIATED RETINOPATHY [J].
KELTNER, JL ;
THIRKILL, CE ;
TYLER, NK ;
ROTH, AM .
ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (01) :48-53
[6]  
KORNGUTH SE, 1982, CANCER, V50, P1289, DOI 10.1002/1097-0142(19821001)50:7<1289::AID-CNCR2820500711>3.0.CO
[7]  
2-9
[8]   CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].
LAEMMLI, UK .
NATURE, 1970, 227 (5259) :680-+
[9]   BLINDNESS CAUSED BY PHOTORECEPTOR DEGENERATION AS A REMOTE EFFECT OF CANCER [J].
SAWYER, RA ;
SELHORST, JB ;
ZIMMERMAN, LE ;
HOYT, WF .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1976, 81 (05) :606-613
[10]   CANCER-ASSOCIATED RETINOPATHY (CAR SYNDROME) WITH ANTIBODIES REACTING WITH RETINAL, OPTIC-NERVE, AND CANCER-CELLS [J].
THIRKILL, CE ;
FITZGERALD, P ;
SERGOTT, RC ;
ROTH, AM ;
TYLER, NK ;
KELTNER, JL .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (23) :1589-1594