ENDOCYTE(C), AN INTERACTIVE COMPUTER-PROGRAM FOR QUANTITATIVE-ANALYSIS OF RECEPTOR-MEDIATED ENDOCYTOSIS

被引：3

作者：

ZELIC, A

BAJZER, Z

VUKPAVLOVIC, S

机构：

[1] MAYO CLIN & MAYO FDN, DIV DEV ONCOL RES, ROCHESTER, MN 55905 USA

[2] MAYO CLIN & MAYO FDN, DEPT BIOCHEM & MOLEC BIOL, ROCHESTER, MN 55905 USA

来源：

INTERNATIONAL JOURNAL OF BIO-MEDICAL COMPUTING | 1992年 / 31卷 / 01期

关键词：

ENDOCYTE(C); RECEPTOR-MEDIATED ENDOCYTOSIS; NESTED MATHEMATICAL MODELS; COMPUTER PROGRAM FOR MACINTOSH(TM)II;

D O I：

10.1016/0020-7101(92)90054-V

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

We present EndoCyte(C), a user friendly interactive program for quantitative analysis of receptor-mediated endocytosis. The data, comprised of time-dependent concentrations of the ligand at the cell surface and the ligand internalized by cells, are analyzed by the application of a set of nested mathematical models of endocytosis. EndoCyte(C) reduces data to parameters conventional in description of receptor-mediated endocytosis and a parameter which describes the non-linear effects. The performance of EndoCyte(C) is documented by the analysis of applications to synthetic data.

引用

页码：59 / 70

页数：12

共 3 条

[1] ENDOCYTE(C) 1.2 - AN IMPROVED ALGORITHM FOR QUANTITATIVE-ANALYSIS OF RECEPTOR-MEDIATED ENDOCYTOSIS
ZELIC, A
BAJZER, Z
VUKPAVLOVIC, S
INTERNATIONAL JOURNAL OF BIO-MEDICAL COMPUTING, 1993, 33 (3-4): : 241 - 248
[2] Kinetic analysis of receptor-mediated endocytosis (RME) of proteins and peptides: Use of RME as a drug delivery system
Kato, Y
Seita, T
Kuwabara, T
Sugiyama, Y
JOURNAL OF CONTROLLED RELEASE, 1996, 39 (2-3) : 191 - 200
[3] KINETICS OF RECEPTOR-MEDIATED ENDOCYTOSIS OF POLYPEPTIDE HORMONES THAT GOVERNS THE OVERALL HORMONE DISPOSITION IN THE BODY - ANALYSIS OF THE UPTAKE PROCESS OF EPIDERMAL GROWTH-FACTOR BY THE LIVER AND KIDNEY
SUGIYAMA, Y
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1991, 111 (12): : 709 - 736

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