Prognostic value of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scan volumetric parameters in head-and-neck cancer patients after treatment

被引：2

作者：

Karam, Mehrdad Bakhshyesh ^{[1
]}

Doroudinia, Abtin ^{[2
]}

Goodarzi, Sheida Bashiri ^{[2
]}

Kaghazchi, Fatemeh ^{[2
]}

Koma, Abbas Yousefi ^{[3
]}

Mehrian, Payam ^{[4
]}

Alizadeh, Niloufar ^{[2
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Pediat Resp Dis Res Ctr, Natl Res Inst TB & Lung Dis, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Chron Resp Dis Res Ctr, Natl Res Inst TB & Lung Dis, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Natl Res Inst TB & Lung Dis, Lung Transplantat Res Ctr, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Telemed Res Ctr, Natl Res Inst TB & Lung Dis, Tehran, Iran

来源：

BIOMEDICAL AND BIOTECHNOLOGY RESEARCH JOURNAL | 2018年 / 2卷 / 03期

关键词：

Head-and-neck squamous cell carcinoma; metabolic tumor volume; overall survival; standardized uptake value; total lesion glycolysis;

D O I：

10.4103/bbrj.bbrj_75_18

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: A few studies have evaluated the predictive value of fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) in patients with head-and-neck squamous cell carcinoma (HNSCC). Methods: We performed a retrospective study on 32 HNSCC patients, undergoing PET/CT after completion of planned treatment. The PET/CT volumetric parameters measured separately for primary tumor site and nodal or distant metastases. The primary outcome measure of the study was overall survival. Results: There was significant difference between alive and dead patients regarding some of volumetric parameters. Univariate and multivariate Cox regression analyses demonstrated association between metabolic tumor burdens with survival outcome. There was also significant difference in time to survival between patients with metastatic metabolic tumor burden and metastatic total lesion glycolysis (TLG) above and below 50th percentile. Conclusion: PET/CT volumetric parameters including metabolic tumor burden and TLG are significant prognostic markers for overall survival of patients with primary HNSCC after treatment.

引用

页码：196 / 202

页数：7

共 34 条

[1] Does 18F-FDG PET/CT Improve the Detection of Posttreatment Recurrence of Head and Neck Squamous Cell Carcinoma in Patients Negative for Disease on Clinical Follow-up? [J].