EVIDENCE FOR A ROLE OF IFN-GAMMA IN CONTROL OF LISTERIA-MONOCYTOGENES IN T-CELL DEFICIENT MICE

被引：3

作者：

LEIST, TP ^{[1
]}

MEAGER, A ^{[1
]}

EXLEY, T ^{[1
]}

ZINKERNAGEL, RM ^{[1
]}

机构：

[1] NATL INST BIOL STAND & CONTROLS,POTTERS BAR EN6 3QG,HERTS,ENGLAND

来源：

EXPERIENTIA | 1991年 / 47卷 / 06期

关键词：

T-CELL DEFICIENT MICE; NUDE MICE; T-SUBSET DEPLETED MICE; INTERFERON-GAMMA; LISTERIA-MONOCYTOGENES;

D O I：

10.1007/BF01949893

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of interferon (IFN) gamma in controlling chronic infections of Listeria monocytogenes (Listeria) was studied in athymic C57BL/6 nu/nu mice, and by treating thymectomized C57BL/6 +/+ mice with monoclonal rat CD4 and CD8-specific monoclonal antibodies (Mab). Mice treated with a combination of the two T cell subset antibodies were similar to athymic, nude mice in being able to contol Listeria infection, keeping the titers below 3-5 log10 bacteria per organ, but they could not eliminate them completely. Treatment with antibodies to IFN gamma of nude or CD4+ + CD8+ - T cell-depleted mice suffering from chronic Listeria infection caused a marked increase of Listeria titers in liver and spleen. This result implies a role of IFN gamma in maintaining anti-Listeria resistance in mice lacking mature T cells.

引用

页码：630 / 632

页数：3

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