SOLID LIPID NANOPARTICLES FOR ENHANCEMENT OF ORAL BIOAVILABILITY OF CEFPODOXIME PROXETIL

被引:9
作者
Nimbalkar, U. A. [1 ]
Dhoka, M. V. [1 ]
Sonawane, P. A. [1 ]
机构
[1] AISSMS Coll Pharm, Kennedy Rd, Pune, Maharashtra, India
关键词
Solid Lipid Nanoparticles; Solvent Evaporation Technique; Cefpodoxime Proxetil; Precirol ATO 5; Lymphatic Absorption;
D O I
10.13040/IJPSR.0975-8232.2(11).2974-82
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Solid lipid nanoparticles (SLNs) have been proposed as suitable colloidal carriers for delivery of drugs with poor bioavailability. The objective of this study was to develop and evaluate solid lipid nanoparticles of Cefpodoxime Proxetil (CP) for enhancement of bioavailability via its lymphatic absorption. Solvent evaporation technique was adopted to prepare Cefpodoxime Proxetil loaded SLN with Precirol ATO 5 as a carrier with narrow size distribution. The mean particle size, drug entrapment efficiency (%), zeta potential and long term physical stability were investigated in detail. Drug release from Cefpodoxime Proxetil-Solid lipid nanoparticles (CP-SLN) was studied using a Franz diffusion cell. A pharmacokinetic study was conducted on male rats after oral administration of CP and CP-SLN. It was found that the relative bioavailability of CP with SLNs was significantly increased as compared with oral CP suspension. FTIR and DSC study revealed that drug is completely encapsulated in lipid matrix. Dry powder for reconstitution was selected as dosage form for the oral administration of CP-SLNs. These results indicated that bioavailability of CP was improved when formulated as SLNs due to its lymphatic absorption.
引用
收藏
页码:2974 / 2982
页数:9
相关论文
共 14 条
[1]  
Bruce JA, J PHARM SCI, V82, P979
[2]   Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil [J].
Date, Abhijit A. ;
Nagarsenker, M. S. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 329 (1-2) :166-172
[3]  
Driscol MC, EUR J PHARM SCI, V15, P405
[4]   Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system [J].
Hu, FQ ;
Jiang, SP ;
Du, YZ ;
Yuan, H ;
Ye, YQ ;
Zeng, S .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2005, 45 (3-4) :167-173
[5]   Investigation of factors responsible for low oral bioavailability of cefpodoxime proxetil [J].
Kakumanu, Vasu Kumar ;
Arora, Vinod ;
Bansal, Arvind K. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 317 (02) :155-160
[6]  
Kheradmandnia S, 2010, J NANOMEDICINE, P62
[7]   Development and evaluation of nitrendipine loaded solid lipid nanoparticles: Influence of wax and glyceride lipids on plasma pharmacokinetics [J].
Kumar, Venishetty Vinay ;
Chandrasekar, Durairaj ;
Ramakrishna, Sistla ;
Kishan, Veerabrahma ;
Rao, Yamsani Madhusudan ;
Diwan, Prakash Vamanrao .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 335 (1-2) :167-175
[8]   Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability [J].
Luo, YiFan ;
Chen, DaWei ;
Ren, LiXiang ;
Zhao, XiuLi ;
Qin, Jing .
JOURNAL OF CONTROLLED RELEASE, 2006, 114 (01) :53-59
[9]   Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art [J].
Müller, RH ;
Mäder, K ;
Gohla, S .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 50 (01) :161-177
[10]   Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery [J].
Paliwal, Rishi ;
Rai, Shivani ;
Vaidya, Bhuvaneshwar ;
Khatri, Kapil ;
Goyal, Amit K. ;
Mishra, Neeraj ;
Mehta, Abhinav ;
Vyas, Suresh P. .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2009, 5 (02) :184-191