CRYSTAL-STRUCTURE OF A COMPLEX BETWEEN INTERFERON-GAMMA AND ITS SOLUBLE HIGH-AFFINITY RECEPTOR

被引：339

作者：

WALTER, MR

WINDSOR, W

NAGABHUSHAN, TL

LUNDELL, DJ

LUNN, CA

ZAUODNY, PJ

NARULA, SK

机构：

[1] UNIV ALABAMA, CTR MACROMOLEC CRYSTALLOG, BIRMINGHAM, AL 35294 USA

[2] SCHERING PLOUGH CORP, RES INST, KENILWORTH, NJ 07033 USA

来源：

NATURE | 1995年 / 376卷 / 6537期

关键词：

D O I：

10.1038/376230a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 Angstrom. Upon receptor binding, the flexible As loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.

引用

页码：230 / 235

页数：6

共 49 条

[1] MOLECULAR-CLONING AND EXPRESSION OF THE HUMAN INTERFERON-GAMMA RECEPTOR [J].