DIVERSITY OF G-PROTEINS IN SIGNAL TRANSDUCTION

被引：1807
作者：
SIMON, MI [1 ]
STRATHMANN, MP [1 ]
GAUTAM, N [1 ]
机构：
[1] WASHINGTON UNIV, SCH MED, DEPT ANESTHESIOL, ST LOUIS, MO 63110 USA
来源：
SCIENCE | 1991年 / 252卷 / 5007期
关键词：
D O I：
10.1126/science.1902986
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors. The G proteins are present in all eukaryotic cells, and they control metabolic, humoral, neural, and developmental functions. More than a hundred different kinds of receptors and many different effectors have been described. The G proteins that coordinate receptor-effector activity are derived from a large gene family. At present, the family is known to contain at least sixteen different genes that encode the alpha subunit of the heterotrimer, four that encode beta subunits, and multiple genes encoding gamma subunits. Specific transient interactions between these components generate the pathways that modulate cellular responses to complex chemical signals.
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页码：802 / 808
页数：7
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